(Facebook, Blended)

Though not together in real life, the two have played love interests in two, soon-to-be three, films. They starred in the hit 1994 film, “The Wedding Singer,” reunited in 2004 to make “50 First Dates,” and will celebrate their 20th anniversary as co-stars with “Blended,” set to come out in May.

“Every 10 years, we get to fall in love again,” Barrymore said when the two stopped by "The Tonight Show Starring Jimmy Fallon" this week.

Following their interview, the two sang a heartwarming and hilarious song, accompanied by Fallon on the acoustic guitar, about their onscreen romances. Some of the best lines included Barrymore’s comparing her and Sandler to Ginger Rogers and Fred Astaire, only to have Sandler compare them to Rob Ford and crack cocaine.

But the duet ended on a sweet note when Sandler serenaded Barrymore with a few lines of “Grow Old With You,” from “The Wedding Singer.”

Watch the whole song below:

Reach Staff Reporter Alex Reed here.