Blanco pioneered drug cartels that shipped from Colombia to Miami. (Wikimedia Commons)

The Spanish newspaper El Colombiano said the 69-year-old was walking out of a butcher shop when she was shot to death at close range. A spokesman for the Medellin police said witnesses heard the motorcycle engine along with two gunshots.

Blanco, also known as "The Black Widow" and "Queen of Cocaine," grew to notoriety after she pioneered drug trafficking routes from Colombia to Miami in the 70s and 80s. The pipelines shipped more than a ton and a half of cocaine per month and evolved into the current model for illegal drug activity.

Under her orders, she allegedly took hits on dozens of people as she launched vicious ambushes against competing traffickers, which would become the hallmark of the "cocaine cowboys."

USA Today reported Blanco served 18 years in a United States prison for drug trafficking and three murders, before she was deported to Colombia in 2004.

Her daughter-in-law, who was with Blanco when she was gunned down, said Blanco no longer had ties to organized crime.

Reach Supervising Executive Producer Amanda Martinez here.