UPDATE: Following a $2 billion loss in its derivatives portfolio, Chief Investment Officer Ina Drew has retired from JPMorgan Chase. Drew was one of the highest paid women in the financial industry, earning $15 million in 2010, according to CNN. She has worked at JPMorgan for more than 30 years.

Drew will be replaced by Matt Zames, the head of global fixed income at the firm, Bloomberg reported. The London staff at the chief investment office where the losses occurred may also be at risk of dismissal.

The massive losses, which were announced Thursday night, were the result of a failed hedging strategy, the New York Times reported. Drew had repeatedly tried to resign after losses became apparent in April but CEO Jamie Dimon had refused to accept the resignation until now. Two of Drew's subordinates who were involved in the losses, Achilles Macris and Javier Martin-Artajo, are expected to be asked to leave as well, according to Reuters. 

"There's almost no excuse for it," Dimon said on "Meet the Press" Sunday. He also admitted that the bank had been "sloppy" and "stupid."

The blunder has given ample ammunition to advocates of financial regulation. Sen. Carl Levin co-authored the so-called Volcker rule to restrict proprietary trading by banks which have federally-insured deposits. He told "Meet the Press" that the cost of JPMorgan Chase's loss will include its inability to resist stricter regulations.

"The real problem here is the battle is not just between Washington and Wall Street," Levin said. "The battle is inside of Washington."

According to the San Francisco Chronicle: 

Dimon has been a critic of Dodd-Frank provisions including the Volcker rule, which is meant to restrict proprietary trading by banks with federally insured deposits.

Elizabeth Warren, a Massachusetts candidate for U.S. Senate, called on Dimon to step down as a director at the Federal Reserve Bank of New York.

"He advises the Federal Reserve on the oversight of the financial industry," Warren said yesterday in an e- mailed statement. "Dimon should resign from his post at the New York Fed to send a signal to the American people that Wall Street bankers get it, and to show that they understand the need for responsibility and accountability."

Fed officials are gathering more information about the trading position, which they have known about for several weeks, according to a person familiar with the matter.

Until the losses were announced, Drew had been considered one of the industry's best managers of balance sheet risk and earned more than $15 million for each of the past two years.

CEO Jamie Dimon said the bank is continuing to investigate what happened and that disciplinary measures would be taken. 

[View the story "Follow reaction to the resignation:" on Storify]